The active ingredient of poison ivy that causes an allergic reaction in humans is Urushiol. Urushiol is an oil in the sap of the plant. Sap runs through all parts of the plant, so a person can get the negative effects from touching not only the leaves, but also the stem and roots. However, just because you were not exposed to the plant does not mean you are safe from the rash. Urushiol is remains potent on items that have been in contact with the plant. For example if you pulled out a poison ivy plant from your garden wearing gloves and then two months later touched the outside of the gloves there is a good chance you will have the allergic reaction. The urushiol binds with the proteins in the fatty cells beneath the epidermis.