Mesodon andrewsae is on the Federal Species of Concern list, which means that the species population is threatened, but it is not conclusive as to whether it is fully endangered.  By being on the list, additional data is being collected to learn more about the status of the species.

The species was first recorded and documented by W.G. Binney in 1878.  The species was discovered on the south-west slope of Roan Mountain in Tennessee which is part of the Great Smoky Mountains (Binney, 1878). 

The range of Mesodon andrewsae includes parts of North Carolina, Tennessee, Virginia and West Virginia in the eastern United States.

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