Phyranosoma cornutum have a certain amount of communication between each other. For example, when males feel like their territory is being invaded by another male. The native male will claim his territory by standing on the boundary of his claim and bob his  head vigorously.  If a challenging male returns the bob, then the claiming male moves on to doing push-ups. This is an advanced warning to back off or else. Finally if the push-ups don't impress or scare off the intruder, the males will fight. This often leads to biting if needed. This fighting is not only over territory but can also be for breeding rights (Manaster).

    These creatures don't just interact with each other. They also run into a human now and again. The problem is that they are only about 3 inches long and often blend into the sand or rock. This interaction takes place between the lizard and the bottom of the unfortunate persons foot. The spines all over its body are the least of your worries. These lizards pack a mean punch with their mouths. It's not just the bite but its also the mouth full of dangerous bacteria that it inflicts with the injury  (Manaster).