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Protein Evolution

Much of the material in this lecture was borrowed from the following site.

http://www.life.sci.qut.edu.au/collet/608_l11/sld005.htm

 

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Different proteins mutate at different rates.

 

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Science.  Volume 274, Number 5287, Issue of 25 Oct 1996, pp. 568-573.

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Gene Duplication Provides Template for New Proteins to Evolve

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Domains are often contained on Exons.  Duplication of an exon leads to duplication of the domain.

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Gene and Genomes can duplicate:  starting point for evolution of new protein families

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Duplication and mutation can explain protein family evolution, but not the immense diverstiy observed in eukaryotic proteins.  Domain shuffling = Exon shuffling.

Introns provide site for recombination without worrying about changing reading frames.  One explanation for eukaryotes tolerating introns and other ``useless" DNA.

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In addition, we can change how we splice mRNA, giving different combinations of proteins from one mRNA.

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